About Us
Radical Numerics is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering.
Our team created Evo, and started the field of generative genomics. Our work was featured on the cover of Science, and presented by our CEO on the main stage of TED2025. Evo was used to create the first AI gene therapy tool CRISPR-Cas9, and the first AI whole genome from scratch. Evo 2, featured in Nature, is the largest fully open source AI project across any domain.
Radical Numerics is bringing the rigor of distributed systems, model architecture, and numerics research to the challenges of biology. We’ve redesigned the foundation model training stack to turn the world’s raw scientific data (e.g. biological sequences, experiments, and physical processes), into intelligible, generative models that can expand and accelerate what humanity can understand, design, and cure.
The same generative breakthroughs that enable life-saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons. We believe these forces are inseparable. Radical Numerics was founded to develop both the power to design and the responsibility to defend.
About the Role
As a Member of Technical Staff, Biosecurity at Radical Numerics, you will lead the design, evaluation, and deployment of biosecurity systems for biological foundation models. You will build evaluation frameworks, define safety architecture, and work with government and external partners to translate technical capabilities into real-world biosecurity infrastructure.
This role blends research and engineering. You should be excited to move fluidly between technical depth and external engagement: understanding model behavior, building red-teaming and evaluation pipelines, designing system-level safeguards, and working with stakeholders to deploy biosecurity systems at scale.
We believe biology will be the most impactful and consequential application of AI—and that advancing capabilities must go hand-in-hand with advancing safety and biosecurity. The same systems that design biology must also help defend against it. This role is focused on building and deploying the technical systems that make biosecurity real.
What You'll Do
Design and run biosecurity evaluations. Develop evaluation frameworks for biological foundation models covering sequence generation risk, synthesis screening evasion, and capability assessment across genomics, proteins, and multimodal systems. Build red-teaming pipelines and define benchmarks that measure real-world risk and misuse potential.
Work directly with models and data. Prototype pipelines for pathogen detection, sequence classification, anomaly detection, and risk scoring of biological sequences or designs. Collaborate with research teams to understand model behavior, identify dangerous capabilities early, and inform model design with safety constraints.
Define safety architecture. Help design system-level safeguards including access controls, gating, monitoring, human-in-the-loop review, and deployment constraints for sensitive capabilities. Contribute to internal safety standards and release policies.
Bridge to real-world biosecurity systems. Translate technical capabilities into deployable systems such as biosurveillance platforms, sequence screening tools, and rapid detection and response pipelines. Work with government and partners to align systems with real-world workflows.
Drive partnerships and external engagement. Engage with government agencies, help shape joint technical programs and pilots, and communicate model capabilities, risks, and mitigations clearly to stakeholders.
Identify new opportunities. Discover product and platform opportunities in biosecurity, help define Radical Numerics' role in global biological risk infrastructure, and operate with high ownership in a fast-moving, ambiguous environment.
What We're Looking For
Strong technical background in at least one of: machine learning and AI systems (especially large models), computational biology and bioinformatics, or biosecurity and biodefense with technical depth.
Ability to reason concretely about what biological AI systems can and cannot do, how those capabilities translate into real-world risks, and how to measure and mitigate those risks.
Experience building or working with ML systems, or strong computational biology experience.
Ability to design evaluations, benchmarks, or experimental frameworks for biological data, including genomic sequences, pathogens, protein data, or multi-omics.
Strong intuition for failure modes, adversarial behavior, and misuse risks, with the ability to translate ambiguous risks into concrete technical work.
High agency: defines problems, runs with them, and ships.
Excellent written and verbal communication skills, especially the ability to engage credibly with government, labs, and policy stakeholders and translate technical systems into clear narratives.
Nice to Have
Experience with pathogen genomics, bio-surveillance, or DNA synthesis screening.
Background in AI safety, red-teaming, or model evaluations.
Familiarity with hybrid systems such as BLAST + ML or retrieval + generation pipelines.
Experience with models like Evo, ESM, AlphaFold, or genomic foundation models.
Background in biodefense, intelligence, or global health security.
Existing network across government, national labs, or global health organizations.
Why Radical Numerics
Help build the multimodal biological world models needed for rapid detection, response, and countermeasures across global health.
Work directly on frontier biological AI systems and define how they are evaluated, controlled, and deployed.
Help shape global infrastructure for biological risk detection and response.
Radical Numerics is committed to equal employment opportunity and does not discriminate in any employment opportunities or practices based on an individual's race, color, creed, gender (including gender identity and gender expression), religion (all aspects of religious beliefs, observance or practice, including religious dress or grooming practices), marital status, registered domestic partner status, age, national origin or ancestry (including language use restrictions and possession of a driver’s license issued under California Vehicle Code section 12801.9), natural hair, physical or mental disability, political affiliation, medical condition (including cancer or a record or history of cancer, and genetic characteristics), sex (including pregnancy, childbirth, breastfeeding or related medical condition), genetic information, sexual orientation, military and veteran status or any other consideration made unlawful by federal, state, or local laws. It also prohibits unlawful discrimination based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.
Radical Numerics participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.